It’s now widely recognised that a One Health approach is needed to address the global antimicrobial resistance (AMR) crisis. But what does that mean in practice? Even when the connections between AMR evolution, transmission, and stakeholder practices are clearly indicated through a growing evidence base, changing practices to mitigate AMR remains challenging. The Australian Cooperative Research Centre for Solving Antimicrobial Resistance in Agribusinesses, Food and Environments (CRC SAAFE) has recently been established to help meet this challenge. This presentation will introduce the CRC scope and provide more information on Australia’s One Health AMR journey ahead.