Not all microbes cause deadly disease, and some might even hold the key to a greener and cleaner future. To this end, our team develops the world’s fastest-growing marine bacterium, Vibrio natriegens, into a new chassis for a sustainable biotechnology. With a cell doubling time of less than 10 minutes, it has tremendous potential as a self-replicating cell factory for the bio-production of valuable enzymes, chemicals, and polymers. In this talk, I will report on our work-in-progress towards building VibrioPET - an engineered V. natriegens strain that will feed on polyethylene terephthalate (PET) plastics as the sole carbon source. Together with our efforts to build VibrioPHA - a second V. natriegens strain that turns CO2 emissions via a hybrid chemo-biological approach into biodegradable polyhydroxyalkanoate (PHA) polymers, we set this superbug to tackle the world’s plastic pollution head on.