A critical step in the process of converting renewable resources into valuable biomaterials is the proper metabolic process to produce the target chemicals from fermentable sugars. Thus, the designed microbes based on systems metabolic engineering and protein engineering are a key biological technology for the production of valuable products. Porphyrin is a heterocyclic macromolecule, which is composed of four pyrrole subunits connected with methine groups. Porphyrin extensively absorbs UV-visible light and is being used as a high-value chemical in various fields because of its unique structure. Corynebacterium glutamicum is one of the attractive designed microbes to produce porphyrin derivatives, because it can produce various amino acids, which are their precursors, and is being used in the industry. Thus, designing metabolic pathways of this industrial microbe to tailor the porphyrin production is a key biotechnology and can be alternative process for large-scale and high-yield production. First, metabolic engineering of the heme biosynthesis pathway including precursor aminolevulinic acid pathways and the core intermediate heme pathway improved the production of Zn-uroporphyrin III (Zn-UP III) and Zn-coproporphyrin III (Zn-CP III). The cream including Zn-UP III and Zn-CP III showed high transmittance of the UV-A wavelength. The biorenewable sunscreen including Zn-porphyrins and lignins from lignocellulosic biomass showed the sun blocking effect on the broad-spectrum UV wavelength. Second, systems metabolic engineering of the downstream heme pathway with the transcriptional upregulation of heme biosynthesis gene operons in C. glutamicum improved heme production. Then, membrane engineering of this metabolically engineered strain by disrupting heme-binding membrane proteins and fatty acid layers showed enhanced heme secretion. Heme could be used as a meaty flavor ingredient in the food industry. In conclusion, the development of the microbial cell factories for enhanced porphyrin production could be an attractive strategy for their industrial production and application. Furthermore, the intelligent application of porphyrins may offer benefits to various areas related to photosensitive biomaterials.